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RESEARCH DIRECTION

研究方向

长期记忆的神经编码与阿尔茨海默症中的记忆编码异常

新皮层对感觉信号的短期记忆编码及在心盲症（aphantasia）中的异常

进一步开发基于光学的单细胞精度基因编辑及神经活动控制的新工具

PAPER PUBLISHED

论文发表

2025

02-21

Neuronal FAM171A2 mediates α-synuclein fibril uptake and drives Parkinson’s disease

KAI-MIN WU , QIAN-HUI XU, YI-QI LIU , YI-WEI FENG , SI-DA HAN, YA-RU ZHANG, SHI-DONG CHEN, YU GUO, BANG-SHENG WU, LING-ZHI MA, YI ZHANG, YI-LIN CHEN, LIU YANG, ZHAO-FEI YANG , YU-JIE XIAO , TING-TI...

2024

12-17

Stable sequential dynamics in prefrontal cortex represents subjective estimation of time

Stable sequential dynamics in prefrontalcortex represents subjective estimationof timeYiting Li1,2†, Wenqu Yin1†, Xin Wang2, Jiawen Li1,3, Shanglin Zhou4, Chaolin Ma1*,Peng Yuan2*, Baoming Li1,5*Ab...

2024

12-07

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in MiceDOI:10.3791/66916⸱August 2nd, 2024Shanshan Han1, Ning Ding1, Ce Li1, Peng Yuan1AbstractReal-time approaches are t...

2023

11-24

Specific serum autoantibodies predict the development and progression of Alzheimer’s disease

Specific serum autoantibodies predict the development and progression of Alzheimer’s disease with high accuracyAbstractAutoimmunity plays a key role in the pathogenesis of Alzheimer’s disease (AD)....

2023

09-18

Single cell in vivo optogenetic stimulation by two-photon excitation fluorescence transfer

Optogenetic manipulation with single-cell resolution can be achieved by two-photon excitation. However, this frequently requires relatively high laser powers. Here, we developed a novel strate...

2023

03-20

EMBER multidimensional spectral microscopy enables quantitative determination of disease- and

cell-specific amyloid strainsSignificanceIn neurodegenerative diseases, proteins fold into amyloid structures with distinct conformations (strains). There is a need to rapidly identify these amyloi...

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组内新闻

Science | “从0到1”，本院袁鹏团队合作发现帕金森病治疗全新原创靶点和候选新药

复旦大学脑科学转化研究院袁鹏团队与附属华山医院郁金泰教授团队和中科院上海有机化学研究所生物与化学交叉研究中心刘聪教授团队合作在帕金森病发病机制研究和候选药物开发方面取得新突破。相关成果以“Neuronal FAM171A2mediates α-synuclein fibril uptake and drives Parkinson’s disease”为题，于2025年2月21日在线发表于《...

Nature|我院袁鹏合作发现损害阿尔茨海默症中神经网络功能的新机制

2022年11月30日，我院青年研究员袁鹏与美国耶鲁大学Grutzendler团队合作，于Nature在线发表文章“PLD3 affects axonal spheroids and network defects in Alzheimer’s disease”（1），发现阿尔茨海默症中β-淀粉样蛋白沉积周围存在大量的轴突球状体的膨大病变结构，它们阻碍神经信号传导，影响神经网络功能，而溶酶体...

Nature Communications| 我院袁鹏与加州大学旧金山分校Carlo Condello团队合作，发现CSF1R抑制剂对小鼠具有性别特异性的作用

CSF1R inhibitors induce a sex-specifific resilient microglial phenotype and functional rescue in a tauopathy mouse model我院青年研究员袁鹏与美国加州大学旧金山分校Carlo Condello团队合作，于2023年1月9日在Nature Communications发...