RESEARCH DIRECTION
研究方向
PAPER PUBLISHED
论文发表
2023
03-20
cell-specific amyloid strainsSignificanceIn neurodegenerative diseases, proteins fold into amyloid structures with distinct conformations (strains). There is a need to rapidly identify these amyloi...
2023
02-07
CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tau
AbstractMicroglia are central to pathogenesis in many neurological conditions. Drugs targeting colony-stimulating factor-1 receptor (CSF1R) to block microglial proliferation in preclinical disease ...
2023
02-07
Abstract: The precise mechanisms that lead to cognitive decline in Alzheimer’s disease are unknown. Here we identify amyloid-plaque-associated axonal spheroids as prominent contributors to neural n...
2022
04-02
ABSTRACT: The blood−brain barrier (BBB) is partially disrupted in brain tumors. Despite the gaps in the BBB, there is an inadequate amount of pharmacological agents delivered into the brain. Thus, ...
2022
04-02
Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid p
Through a comprehensive analysis of organellar markers in mouse models of Alzheimer’s disease, we document a massive accumulation of lysosome-like organelles at amyloid plaques and establish that t...
2022
04-02
Efficient use of two-photon excitation (TPE) microscopy requires knowledge of the absolute TPE action cross sections (ATACSs) of fluorescent probes. However, these values are not available for rece...
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CSF1R inhibitors induce a sex-specifific resilient microglial phenotype and functional rescue in a tauopathy mouse model我院青年研究员 袁鹏与美国 加州大学旧金山分校Carlo Condello团队合作 ， 于2023年1月9日在Nature Communications发...
2022年11月30日，我院青年研究员袁鹏与美国耶鲁大学Grutzendler团队合作，于Nature在线发表文章“PLD3 affects axonal spheroids and network defects in Alzheimer’s disease”（1），发现阿尔茨海默症中β-淀粉样蛋白沉积周围存在大量的轴突球状体的膨大病变结构，它们阻碍神经信号传导，影响神经网络功能，而溶酶体...
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