RESEARCH DIRECTION
研究方向
PAPER PUBLISHED
论文发表
2023
11-24
Specific serum autoantibodies predict the development and progression of Alzheimer’s disease with high accuracyAbstractAutoimmunity plays a key role in the pathogenesis of Alzheimer’s disease (AD)....
2023
09-18
Optogenetic manipulation with single-cell resolution can be achieved by two-photon excitation. However, this frequently requires relatively high laser powers. Here, we developed a novel strate...
2023
08-11
AbstractBackgroundMutations of the gene TMEM106B are risk factors for diverse neurodegenerative diseases. Previous understanding of the underlying mechanism focused on the impairment of lysosome bi...
2023
03-20
cell-specific amyloid strainsSignificanceIn neurodegenerative diseases, proteins fold into amyloid structures with distinct conformations (strains). There is a need to rapidly identify these amyloi...
2023
01-09
CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tau
AbstractMicroglia are central to pathogenesis in many neurological conditions. Drugs targeting colony-stimulating factor-1 receptor (CSF1R) to block microglial proliferation in preclinical disease ...
2022
12-30
Abstract: The precise mechanisms that lead to cognitive decline in Alzheimer’s disease are unknown. Here we identify amyloid-plaque-associated axonal spheroids as prominent contributors to neural n...
GROUP NEWS
组内新闻
2022年11月30日，我院青年研究员袁鹏与美国耶鲁大学Grutzendler团队合作，于Nature在线发表文章“PLD3 affects axonal spheroids and network defects in Alzheimer’s disease”（1），发现阿尔茨海默症中β-淀粉样蛋白沉积周围存在大量的轴突球状体的膨大病变结构，它们阻碍神经信号传导，影响神经网络功能，而溶酶体...
CSF1R inhibitors induce a sex-specifific resilient microglial phenotype and functional rescue in a tauopathy mouse model我院青年研究员 袁鹏与美国 加州大学旧金山分校Carlo Condello团队合作 ， 于2023年1月9日在Nature Communications发...
2024-06-11
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2023-03-20
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