PAPER PUBLISHED
论文发表

2023

11-24

Specific serum autoantibodies predict the development and progression of Alzheimer’s disease with high accuracyAbstractAutoimmunity plays a key role in the pathogenesis of Alzheimer’s disease (AD)....

2023

09-18

    Optogenetic manipulation with single-cell resolution can be achieved by two-photon excitation. However, this frequently requires relatively high laser powers. Here, we developed a novel strate...

2023

08-11

AbstractBackgroundMutations of the gene TMEM106B are risk factors for diverse neurodegenerative diseases. Previous understanding of the underlying mechanism focused on the impairment of lysosome bi...

2023

03-20

cell-specific amyloid strainsSignificanceIn neurodegenerative diseases, proteins fold into amyloid structures with distinct conformations (strains). There is a need to rapidly identify these amyloi...

2023

01-09

AbstractMicroglia are central to pathogenesis in many neurological conditions. Drugs targeting colony-stimulating factor-1 receptor (CSF1R) to block microglial proliferation in preclinical disease ...

2022

12-30

Abstract: The precise mechanisms that lead to cognitive decline in Alzheimer’s disease are unknown. Here we identify amyloid-plaque-associated axonal spheroids as prominent contributors to neural n...
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2022年11月30日,我院青年研究员袁鹏与美国耶鲁大学Grutzendler团队合作,于Nature在线发表文章“PLD3 affects axonal spheroids and network defects in Alzheimer’s disease”(1),发现阿尔茨海默症中β-淀粉样蛋白沉积周围存在大量的轴突球状体的膨大病变结构,它们阻碍神经信号传导,影响神经网络功能,而溶酶体...
CSF1R inhibitors induce a sex-specifific resilient microglial phenotype and functional rescue in a tauopathy mouse model我院青年研究员 袁鹏与美国 加州大学旧金山分校Carlo Condello团队合作 , 于2023年1月9日在Nature Communications发...
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