RESEARCH DIRECTION
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PAPER PUBLISHED
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2022
04-02
ABSTRACT: The blood−brain barrier (BBB) is partially disrupted in brain tumors. Despite the gaps in the BBB, there is an inadequate amount of pharmacological agents delivered into the brain. Thus, ...
2022
04-02
Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid p
Through a comprehensive analysis of organellar markers in mouse models of Alzheimer’s disease, we document a massive accumulation of lysosome-like organelles at amyloid plaques and establish that t...
2022
04-02
Efficient use of two-photon excitation (TPE) microscopy requires knowledge of the absolute TPE action cross sections (ATACSs) of fluorescent probes. However, these values are not available for rece...
2022
04-02
In Alzheimer’s disease (AD), b-amyloid (Ab) plaques are tightly enveloped by microglia processes, but the significance of this phenomenon is unknown. Here we show that microglia constitute a barrie...
2022
04-02
Angiophagy Prevents Early Embolus Washout But Recanalizes Microvessels Through Embolus Extravasation
Occlusion of the microvasculature by blood clots, atheromatous fragments, or circulating debris is a frequent phenomenon in most human organs. Emboli are cleared from the microvasculature by hemody...
2022
04-02
In this report, we designed a highly bright bifunctional curcumin analogue CRANAD-28. In vivo two-photon imaging suggested that CRANAD-28 could penetrate the blood brain barrier (BBB) and label pla...
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